Heal Better. Live Braver.

The World's First PDRN-Infused Bone Graft. Next-Gen Bone Scaffold: The Synergy of PDRN. PDRN Inside: Faster, Stronger, Better.

Medina develops next-generation dental bone graft materials powered by PDRN innovation — for faster, smarter, and stronger regeneration.

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3+
Product Lines
PDRN
Core Technology
GMP
Grade Quality

"Biotech Innovation
for Stronger Regeneration"

— Medina Co., Ltd.
Who We Are

Biotech Innovation
for Stronger Regeneration

At Medina, we believe healing should be faster, stronger, and smarter. Our mission is to create regenerative solutions that empower patients and dental providers worldwide.

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PDRN Technology

Bioactive polynucleotide compounds that accelerate tissue repair at the cellular level.

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Dental Focus

Precision-engineered bone graft materials for implantology and oral surgery.

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Global Vision

Empowering clinicians worldwide with science-backed regenerative solutions.

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Clinical Science

Products validated through rigorous R&D and peer-reviewed research.

Our Mission

Redefining Bone Healing with PDRN

PDRN (Polydeoxyribonucleotide) is a DNA fragment derived from salmon sperm that activates A2A adenosine receptors, stimulating angiogenesis, reducing inflammation, and accelerating tissue regeneration — now embedded directly into our bone graft materials.

Quality Assurance

Raw Material to Product, Total Quality Control

Medina maintains exclusive control over the entire supply chain — from salmon trout aquaculture and DNA extraction to GMP production — ensuring consistent quality from raw material to finished product.

Salmon farm
Aquaculture Farm

Self-Operated Salmon Trout Farm

Oncorhynchus mykiss raised in Pyeongchang, Gangwon — from breeding to DNA extraction, fully in-house.

HACCPMin. of Oceans & Fisheries
GMP facility
Manufacturing

GMP-Level Production Facility

Pharmaceutical-grade PDRN extraction and production with ISO 13485/22716 quality management systems.

ISO 13485ISO 22716GMP
PDRN powder
Raw Material

99%+ DNA Purity PDRN Powder

Pharmaceutical-grade PDRN — 82 safety parameters tested, free of allergens, heavy metals, and bacteria.

COA Provided82 Tests Passed
200kg
Annual PDRN Production
99%+
DNA Purity
82
Safety Tests

Vertically Integrated Supply Chain

From live salmon trout in Pyeongchang to pharmaceutical-grade PDRN powder — every step controlled, certified, and traceable.

PDRN Science

Why PDRN Changes Everything

Our proprietary PDRN integration delivers critical advantages that set Medina products apart from conventional bone grafts.

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Accelerated Bone Regeneration

Upregulates osteoblast activity and BMP expression for faster alveolar bone formation and superior bone density.

Osteogenesis +
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Enhanced Gum Regeneration

Promotes angiogenesis and fibroblast proliferation for faster, healthier gingival tissue recovery around implant sites.

Soft Tissue Healing
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Anti-Inflammatory Effect

Calms post-operative swelling and reduces chronic inflammation through adenosine A2A receptor activation — helping to prevent peri-implantitis and protect long-term implant success.

Inflammation Control
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Antibacterial Action

PDRN inhibits pathogenic bacterial growth at the graft site, reducing post-operative infection risk in dental implant procedures.

Anti-Infective
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Improved Blood Flow

Angiogenic properties enhance vascularization of the graft, ensuring nutrient supply for optimal osseointegration.

Angiogenesis
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Stable Powder Format

No refrigeration or mixing required — simply open and apply. Long shelf life with consistent bioactivity throughout.

Ready-to-Use
Product Portfolio

Our Product Lines

Three precision-engineered solutions for every clinical need — all powered by PDRN innovation.

Raw Bioactive
PDRN Powder

PDRN Powder

Bioactive Stable DNA for Regenerative Use

Pure pharmaceutical-grade PDRN in dry powder form. No cold-chain — stable, long shelf life.

No refrigeration required
Extended shelf life
Gamma sterilized · Single use
Salmon-derived · 99%+ purity
Bacterial Endotoxin < 0.5 EU/mg
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Flagship Product
PDBONE

PDBONE

PDRN 10%
PDRN 20%
Synthetic Bone Graft with PDRN

Flagship synthetic bone graft — HA/β-TCP optimized ratio, bioactivated with PDRN for superior bone formation.

HA 60% · β-TCP 40% (synthetic)
PDRN 10%/20% of total volume
Faster osseointegration
Antibacterial protection
Request Info →
Dual Regeneration
PDBONE Collagen

PDBONE Collagen

PDBONE + Collagen for Soft & Hard Tissue

PDBONE scaffold + type-I collagen for simultaneous hard and soft tissue regeneration in complex defect sites.

Dual tissue regeneration
Type-I collagen matrix
Enhanced gingival healing
Ideal for GBR procedures
Request Info →
Material Science

Optimized Biphasic Calcium Phosphate

HA 60%*:β-TCP 40%*+PDRN 10% / 20%

PDBONE uses a validated biphasic calcium phosphate — HA 60% for structural stability, β-TCP 40% for controlled resorbability and active bone induction.

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Hydroxyapatite (HA) — 60%

Stable osteoconductive scaffold mimicking natural bone mineral for long-term volume maintenance.

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β-TCP — 40%

Resorbable phase stimulating osteogenesis as it degrades, replaced by newly formed host bone.

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PDRN Bioactivation

Infused throughout, PDRN releases bioactive signals for accelerated healing and antibacterial protection.

HA · TCP + PDRN PDRN 10%

HA 60%

Hydroxyapatite — Structural scaffold

β-TCP 40%

Beta-Tricalcium Phosphate — Bioresorbable

Clinical Evidence

Supported by
Peer-Reviewed Research

Medina's PDRN technology is grounded in published clinical and pre-clinical research validating bone regeneration, angiogenesis, and anti-inflammatory activity.

Frontiers in Pharmacology 2017
Pharmacological Activity and Clinical Use of PDRN
Squadrito F, Bitto A, Irrera N, et al.
University of Messina · doi: 10.3389/fphar.2017.00224
Read Full Paper →
Journal of Clinical Periodontology 2024
Adjunctive Effect of PDRN on Bone Formation in Alveolar Ridge Preservation
Ko Y-C, Lee J, Urban I, et al. — Seoul National University
doi: 10.1111/jcpe.13988
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Scientific Reports — Nature 2023
Effect of PDRN on Early Bone Formation in Lateral Bone Augmentation with Immediate Implant Placement
Lee D, Lee J, Seol Y-J, Lee Y-M, Koo K-T.
doi: 10.1038/s41598-023-43213-8
Read Full Paper →
Dentistry Journal — MDPI 2023
Polydeoxyribonucleotides Pre-Clinical Findings in Bone Healing: A Scoping Review
Manfredini M, Poli PP, Beretta M, et al.
University of Milan · doi: 10.3390/dj11120280
Read Full Paper →
Get in Touch

Connect with Medina

Interested in our products, distribution partnerships, or clinical collaboration? We'd love to hear from you.

Let's Work Together

Whether you're a dental clinic, distributor, or research partner, Medina is ready to support your regenerative goals.

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Phone

+82 10 2777 8902

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Address

211, Hwarang-ro, Seoul, Korea

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Website

www.medina.co.kr